My Cancer Journey
– High-Dose Vitamins D3 & K2 –

Dr. Al Danenberg Nutritional Periodontist

February 7, 2021

 

You know me. I’ve treated my body as a study of N=1.

 

When I learned of my dire cancer prognosis in September 2018, I knew that I could not wait 10 more years for the medical community to prove my Unconventional Cancer Protocols would heal (or even possibly cure) my cancer. You see, I didn’t have the luxury of a long-life expectancy. I was given only 3-6 months to live at that time.

 

Life is what it is.

 

So, right away I was motivated to investigate peer-reviewed methods to help heal my body and recreate a robust immune system. I was not looking for methodologies that only one investigator found successful. I wanted therapies that were successfully and repeatedly reported from various researchers throughout the world.

 

Let me be clear! I never developed a cure for cancer. But my independent research has uncovered concepts to improve my immune system. I even developed a set of 5 Tools to measure my success. And this has gotten me to a point today where I am thriving better than most healthy individuals.

 

After my diagnosis, my cancer journey followed unconventional paths with overall success but a few significant setbacks. I have written many Blogs updating my progress, concerns, and tweaks to my protocols. I have been open with my personal experiences.

 

Now, it’s time for another significant tweak. The reason comes from my continuing research. I’m a glutton for uncovering new and exciting aspects in medical science. My challenge comes from connecting the dots, but I do take “creative scientific license”.

 

My discovery: Supplementation of high-dose Vitamin D3 combined with high-dose Vitamin K2 could be positive for the treatment of cancers. Not proven, but possible!

 

 

The Research

Let’s look at the supporting science.

 

  • In 2017, Healthline summarized the metabolic benefits of combining Vitamin D3 with Vitamin K2 supplementation.

 

  • A summary statement in this 2020 VITAL Trial noted: “Our findings, along with results from previous studies, support the ongoing evaluation of vitamin D supplementation for preventing metastatic cancer – a connection that is biologically plausible.”

 

  • Vitamin D deficiency is extremely common in patients with multiple myeloma. Patients with this bone marrow cancer often complain of dull, persistent, generalized musculoskeletal aches and pains with fatigue or decrease in muscle strength. These symptoms may well be the result of Vitamin D deficiency. Here is a 2011 case report of a 63-year-old man with multiple myeloma who was taking chemotherapy. This individual presented with worsening generalized musculoskeletal pain, weakness, and multiple falls. His bone studies showed severe lytic lesions with a very low Vitamin D level of less than 8ng/mL. However, after he was treated with 3000 units of Vitamin D daily, his musculoskeletal pain decreased.

 

  • In a 2015 medical paper, 83 multiple myeloma patients had their 25 Hydroxy Vitamin D levels studied. Those with less than 10 ng/mL were associated with higher number of plasma cells in their bone marrow. When they took vitamin D3 supplementation, their hemoglobin, leukocytes, and erythrocytes increased, while their thrombocytes decreased.

 

  • In this 2017 study, osteoporosis, osteonecrosis and fracture were more prevalent in patients with multiple myeloma who had low blood levels of Vitamin D.

 

  • Another study in 2020 suggested that multiple myeloma patients with deficient 25 Hydroxy Vitamin D levels had a poorer life expectancy.

 

  • In regard to Vitamin K2, this 2015 article describes how Vitamin K2 can promote bone health.

 

  • And in this in vitro study of human myeloma cells, concentrations of Vitamin K2 inhibited the growth of the malignant cells and assisted in inducing self-suicide (or apoptosis).

 

  • This 2018 review of the literature clearly points out the Vitamin K2 can inhibit cancer cell growth.

 

However, high doses of Vitamin D3 can cause hypercalcemia and other toxic side effects. Because of these potential outcomes, it is necessary to include high doses of Vitamin K2 along with Vitamin D3 to improve calcium metabolism and avoid other side effects. Also, it is important to monitor various blood chemistries for possible signs of Vitamin D toxicity. As for Vitamin K2, there has never been a lethal dose detected.

 

 

My New Protocol

So, I have started a new experiment again using my body as the guinea pig. I definitely am NOT recommending any person try this protocol. I have no idea if this will work for me or even if it will be harmful. However, the medical papers I have read suggest this may be beneficial.

 

If you have followed my Unconventional Cancer Protocols, you are aware that I was taking 5000 IU of Vitamin D3 and 320 mcg of Vitamin K2 daily. The most recent result of my 25 Hydroxy Vitamin D blood test showed a level of 62 ng/mL. This blood level is higher than the recommended range for healthy individuals, which is 40 – 60 ng/mL.

 

I began my new protocol on 1/20/21 when I upped my daily doses. I started taking 20,000 IU of Vitamin D3 along with 450 mcg of Vitamin K2. My goal is to raise my 25 Hydroxy Vitamin D blood level to 100-125 ng/mL. At this new level, maybe my malignant plasma cells and dysfunctional IgA antibodies will decrease. I’ll give my body 2-3 more months on this regimen before retesting.

 

This is the only change I’m making to my Protocols. Obviously, I am not a controlled study. But by changing only one variable in my routine, I can come close to being a controlled medical trial of N=1.

 

 

Diagnostic Tests

To refresh your memory, my cancer diagnosis is IgA Kappa Light Chain Multiple Myeloma. My oncologist orders a new CBC (complete blood count) and CMP (complete metabolic panel) every 4 weeks. Every 2-3 months, I have a series of blood tests to evaluate my dysfunctional antibody production from malignant plasma cells. The test is called a Serum Protein Electrophoresis (SPEP) with Immunofixation.  He also orders a 25 Hydroxy Vitamin D blood test about every 3 months.

 

On my calendar, I have a Bone Scan scheduled for March 2021, which will evaluate my overall skeletal strength. And I have my 4th PET Scan scheduled in May 2021.

 

As time goes by, I will report the results from my various tests and scans as they reflect my new Vitamin D3 and Vitamin K2 dosing.

 

My CBC and CMP have been relatively within normal ranges since 1/1/20. However, the results of my current Serum Protein Electrophoresis (SPEP) with Immunofixation continue to be abnormally high. Yet they are lower with little fluctuation since starting my stand-alone immunotherapy of Darzalex in October 2019.

 

Here are two of my Serum Protein Electrophoresis (SPEP) with Immunofixation results as of 1/26/21:

  • Kappa Light Chain, Free: 1060.0 mg/L (normal = 3.3 – 19.4 mg/L)
  • IgA, quantitative: 591 mg/dL (normal = 61 – 437 mg/dL)

 

In May 2021, I expect to have new numbers and information to report.

 

 

Anecdotal Evidence

I am aware of an individual who has a similar diagnosis as I and has started this new dosing protocol of Vitamin D3 and K2 as I just started. After 30 days on this dosing, her IgA level significantly decreased from 634 mg/dL to 300 mg/dL. However, her Kappa Light Chain, which was not elevated at the start, showed minimal reduction. She also reported that her hemoglobin level improved.

 

I must note that this person was taking Ninlaro (a proteasome inhibitor) intermittently. Ninlaro is an oral medication that inhibits proteasomes. Proteasomes break down other proteins that cells no longer need, as well as proteins that are damaged. Ninlaro attaches to the proteasomes and stops them from working properly. This leads to a buildup of damaged and unneeded proteins in the myeloma cells (malignant plasma cells), which causes the myeloma cells to die. But I am sure that proteasomes in healthy cells also are affected by Ninlaro in such a way that healthy cells will no longer be able to rid themselves of damaged and harmful proteins resulting in potentially severe side effects.

 

 

My Bottom Line

Without a doubt, my goal continues to be to maintain a quality life for as long as possible. Longevity has never been (and will never be) a determining factor for me. Avoiding chemical interventions that could destroy my immune system makes absolute sense to me. Why would I want to destroy the natural biochemical pathways of my body, which are critical for my overall health and healing?

 

I am already compromised with bone marrow cancer. In my opinion, my path to wellness is to enhance my body’s ability to fight the fight. If I can crowd out the pathology and replace it with functional cells, I might win this battle.

 

Keep an eye out for my updates in the future. I am excited about reporting additional positive results. You can count on me to be transparent with my successes as well as my lack of successes and failures.

 

I believe I’m here on this planet to share my experiences with all who want to read, hear, and see what I am doing. If I can be a motivational source for you, I have succeeded.

 

If you feel you need to contact me, here is a link to ask your questions. Your email comes directly to me, and I will personally respond to you.

 

 

 

 

Check out my new training on the Better Belly Blueprint! You can watch it HERE.

 

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Dr. Michael Ruscio
Interviews
Dr. Al Danenberg

Dr. Al Danenberg Nutritional Periodontist
July 4, 2018

 

 

 

Dr. Michael Ruscio Interviews Dr. Al DanenbergI met Dr. Michael Ruscio at the Paleo f(x) meeting in Austin in April 2018. Michael suggested we do a Podcast together. So, we made it happen.

 

Dr. Michael Ruscio is a chiropractor, clinical researcher, and author whose practical ideas on healing chronic illness have made him an influential voice in functional and alternative medicine. Michael also provides post-doctoral continuing education. His research has been published in peer reviewed medical journals, and he speaks at integrative medical conferences across the globe. Currently, he is a lead researcher in a pending IBS (irritable bowel syndrome) study.

 

In this interview, Dr. Ruscio and I discuss the profound connections between the gut, the mouth, mitochondria, and chronic disease. I talk about my Periodontal Disease Clinical Study that will be implemented following approval by the Institutional Review Board. We also discuss how improper flossing could lead to receding gums, new testing showing that mouth tissue is a window into your mitochondrial health, and how mouthwashes could lead to high blood pressure.

 

Tooth decay and periodontal diseases are chronic diseases. My research suggests that the gut could be the initial source for chronic disease to manifest. But, once oral diseases take hold, then both the gut and the mouth must be treated in order to gain control of chronic inflammation and further manifestation of chronic disease.

 

Listen to the Podcast. It lasts a little more than an hour, but I think you’ll find it loaded with “pearls” to take home and act upon immediately.

 

 

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Leaky Gut & Periodontal Disease
And All That Jazz

Dr. Al Danenberg Nutritional Periodontist
June 18, 2018

 

 

 

Leaky Gut and Periodontal DiseaseLeaky gut, periodontal disease, and all that jazz (meaning all those bacteria) play an important role in chronic disease. The tube that courses through the body (called the digestive tract, gastrointestinal (GI) tract, or the alimentary canal) is the initial setting for many chronic diseases that could manifest over time.

 

The GI tract starts with your lips and mouth and finally ends at the anus. Interestingly, all of the tissues that line this tube are affected in similar ways. What happens in the small and large intestines will affect the mouth, and what damages the mouth will affect the tissues of the small and large intestines.

 

The living inhabitants on the surface of the digestive tract are bacteria and other microbes that outnumber the quantity of human cells. These microbes are critical for human survival and affect human metabolism, nutrition, physiology, and immune function. When the microbiome is disturbed and when unhealthy microbes take control, then all Hell could break loose resulting in various chronic diseases.

 

One portal of entry for toxic elements to move into the systemic system is a leaky gut (increased intestinal permeability). Eventually, chronic inflammation and chronic disease can result. Periodontal disease is just one of those chronic diseases that can manifest once the gut becomes unhealthy. However, once periodontal disease exists, then it provides another major portal of entry for toxic elements to move into the systemic system – a “leaky periodontal pocket”.

 

Both a leaky gut and a leaky periodontal pocket must be treated.

 

 

Current Medical Research

Recently published medical papers provide an increased understanding about the interplay between a leaky gut, periodontal disease, and all those bacteria inhabiting the mucosal tissues of the GI tract.

 

Read these papers, which offer important medical outcomes. I believe we can connect these “dots” of knowledge and develop a clinical protocol for adjunctive treatment of periodontal disease and more.

 

This 2015 paper pointed out that damage to the gut actually would decrease the body’s ability to maintain a healthy immune system causing potential for various chronic diseases to manifest.

 

This 2018 review described intestinal permeability and resulting multiple sclerosis as well as other chronic diseases.

 

Figueredo, et al. in 2017 demonstrated that inflammatory bowel disease can cause periodontal disease, which is a chronic disease.

 

Bale, et al. in 2017 reviewed the evidence that periodontal disease contributes to atherosclerosis.

 

McFarlin, et al. in 2017 performed a double-blind study where individuals significantly improved intestinal permeability by taking a spore-based probiotic for only 30 days without changing their unhealthy lifestyles.

 

Li, et al. in 2016 showed how periodontal disease is a disease of mitochondrial dysfunction within the gingival fibroblasts.

 

In 2012, Vos, et al. reported that vitamin K2 could rescue damaged mitochondria in fruit flies. 

 

This 2018 review described how vitamin K2 transports out of the liver and then disseminates throughout the body to assist in various biological functions including the prevention of mitochondrial dysfunction.

 

 

My Thoughts

I believe we can connect these “dots” of knowledge.

 

Apparently, there is a relationship between gut issues and periodontal disease. It appears there is a progression from dysbiosis to leaky gut, then to decreased host resistance, and finally to mitochondrial dysfunction and the development of various chronic diseases including periodontal disease.

 

Research suggests that there might be an adjunctive treatment for periodontal disease by treating dysbiosis, repairing the gut membrane with spore-based probiotics, and utilizing vitamin K2 to prevent and repair mitochondrial dysfunction.

 

My goal is to investigate this possible causal relationship. To that end, Andrew Campbell MD, John Abernethy MD, and I wrote a protocol to study my theory. We submitted our Periodontal Disease Clinical Study to the “Institutional Review Board” (IRB) on 5/31/18.

 

If our study is approved by the IRB, Microbiome Labs will sponsor our research, which will be double-blind involving approximately 50 individuals with active periodontal disease. Participants will take a placebo or a supplement for 6 weeks. The daily supplement will consist of spore-based probiotics and vitamin K2.

 

To determine the potential benefits of this supplement, we will measure the depths of infected gum pockets, bleeding in these pockets, and the status of the participants’ mitochondria. At the end of the study, we will repeat these three measurements.

 

I project that there will be a reduction in pocket depth and bleeding as well as an improvement in the health of the mitochondria.

 

If our work demonstrates significant benefits, then other investigators could repeat and elaborate on this research. There might be far-reaching inferences that could be considered if our results are positive.

 

I’m excited to see where this study might go.

 

 

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I was Interviewed for
Wise Traditions Podcast

Dr. Al Danenberg Nutritional Periodontist
May 28, 2018

 

 

 

Podcasts are an amazing vehicle to get a message to the listening public. I really enjoy the opportunity to voice my passion about what means a lot to me. Recently, I was interviewed by Hilda Labrada Gore for the Wise Traditions Podcast that aired May 28, 2018.

 

This Podcast Series, which launched in January 2016, is part of the Weston A. Price Foundation. Wise Traditions Podcast Series now has over 900,000 downloads. Interviews of guests are published weekly and consist of a 30-minute discussion relating to fields of health, food, and farming.

 

The Weston A. Price Foundation is an important organization. It is a nonprofit, tax-exempt charity founded in 1999. Its goal is to disseminate the research of Dr. Weston A. Price, a dentist who was the chairman of the National Dental Association from 1914 to 1928. Dr. Price studied isolated non-industrialized peoples. He established parameters of human health and determined optimum characteristics of human diets. His research demonstrated that humans achieve health when they consume nutrient-dense whole foods and the vital fat-soluble “activators” found in animal fats.

 

I had fun doing this interview. Take 33 minutes of your time and listen to me and my interviewer, Hilda Labrada Gore, as I describe my views for gut health and dental health including my 5 tweaks for overall health.

 

 

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My 5 Essential Lifestyle Tweaks

Dr. Al Danenberg Nutritional Periodontist
April 2, 2018

 

 

 

My 5 Essential Lifestyle TweaksThis month, I start my 6th year of living a Primal Lifestyle. I wrote about My Primal Lifestyle in 2016. Since then, I refined and perfected the ways I do things. Over the last 12 months, I began to incorporate my 5 Essential Lifestyle Tweaks to further improve what I had been doing.

 

Back in 2007, I had a stroke and could have died. Yet, I didn’t learn about a primal diet and a primal way of living until 2013. Fortunately for me, embracing a Primal Lifestyle in 2013 saved my life.

 

Fast forward to April 2018 when I will be 71 years old. I feel healthier today than I have ever felt. My blood chemistries have improved considerably from where they were in 2013 – with additional impressive test results since I included these 5 tweaks.

 

Following my stroke in 2007, my physicians prescribed 7 medications for me to take for the rest of my life. Not being comfortable with that scenario, I reinvented my life and have weaned off my last medication this month.

 

The way I live is based on a nutrient-dense diet, efficient exercise, restorative sleep, and stress reduction – all of which I discuss in my book, Crazy-Good Living. In addition to all this, recent medical research is uncovering new and exciting facts about the importance of the gut microbiome and the mitochondria. Both areas are where I have refined and focused my current efforts.

 

The Gut & The Mitochondria

I recently published two articles – one about the gut and one about mitochondria. Big Bang Theory of Chronic Disease describes the importance of the gut as the starting point for most systemic diseases. Mitochondria, Gut Bacteria, and Vitamin K2 describes the importance of mitochondrial health for the proper function of almost every cell and organ system. Both articles are loaded with links to peer-reviewed medical papers to support my conclusions.

 

5 Essential Lifestyle Tweaks

The following 5 tweaks are focused methods, which I have added to my primal lifestyle program. They are reported to improve the gut microbiome and the body’s mitochondria:

 

1  Intermittent fasting and multi-day fasting
Published medical research has demonstrated that fasting is beneficial in a variety of ways. It improves fat-burning, builds muscle, enhances brain health, reduces oxidative stress, improves mitochondria health, and reduces inflammation to name a few. Several months ago, I wrote about my fasting experience.

 

2. 4-minute daily exercise created by Dr. Zachary Bush
This may be as effective as high intensity interval training. It is reported to increase the production of nitric oxide. I try to include this exercise protocol several times a week.

 

3. Spore-based probiotics
A randomized and double-blind study published in 2017 demonstrated that spore-based probiotics grow in the gut and can increase the diversity of other healthy bacteria in the gut. Personally, I take this probiotic daily along with the Vitamin supplement I discuss next.

 

4. Vitamin K2
This unique form of vitamin K helps prevent inflammation and move calcium into the proper areas in the body. In addition, medical research using an animal model showed that vitamin K2 could rescue damaged mitochondria.

 

5. Pulsed electromagnetic fields
Pulsed electromagnetic field therapy improves the energy of cells. In this way, it may improve the functioning of mitochondria, and thereby improve many chronic conditions. In the next few weeks, I will devote an entire Blog to the science and application of this important medical application. One company that offers this technology in the United States is QRS (Quantum Resonance Systems).

 

Wrapping It Up

I have experienced personal benefits from these 5 tweaks. My results are anecdotal; I am not part of a controlled study. You may not have the same effects as I have. The facts are that the gut microbiome is critical for overall health, and the mitochondria in every cell of our body are critical for the healthy functioning of each cell.

 

 

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Bacteria, Mitochondria, Gum Disease:
A Critical Cycle

Alvin H. Danenberg, DDS Nutritional Periodontist
January 2, 2018

Critical Cycle

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Here is an account that unfolds like the best science fiction tale ever written. It’s the relationship between bacteria and mitochondria, and eventually gum disease. This relationship forms a critical cycle.

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A long, long time ago – about 4 billion years ago – life began on earth as a single-celled organism with no nucleus. [1] Fast forward 2 billion years.

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About 2 billion years ago, bacteria were among the first living organisms. Some of these single-celled bacteria fed on organic compounds to create energy. These bacteria created carbon dioxide and hydrogen as waste products. Other single-celled organisms in existence at the same time fed only on carbon dioxide and hydrogen. Then, an extraordinary and life-changing event occurred.

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A few of the bacteria producing energy from organic compounds successfully entered some of these single-celled organisms, which could not create their own energy from organic compounds. Eventually, these bacteria set up shop in their host cells. The invading bacterial cells created energy for their single-celled host organisms. Now the host cells, with a self-contained energy source from the resident bacteria, could evolve into multi-celled and more-complex entities. The gradual development of these structures eventually led to the makeup of our human cells, each with a self-contained energy-production machine. The origin of this energy-production machine was ancient bacteria. These organelles are called mitochondria.

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Every cell in our body, with the exception of red blood cells, has mitochondria to create the energy to keep it alive. The mitochondria are embedded within the cytoplasm of our 10 trillion human cells. Some individual cells have only a few mitochondria; our most active cells (like heart muscle) may contain as many as 2,400 mitochondria per cell. If these bacteria-like structures in our body’s cells did not function properly, we would get sick – very sick – and eventually would die.

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Functions of Mitochondria

The mitochondria primarily are the batteries of the cell. If the batteries fail, the cell ultimately dies. However, energy production is not the only purpose of our mitochondria. [2] Mitochondria also produce heat as necessary, assist in calcium signaling within the host cell and throughout the body, and will induce cell death (apoptosis) when its host cell is damaged beyond repair. In addition, mitochondria regulate insulin in the cell, synthesize cholesterol and other steroids, and participate in other functions required by specialized cells. Another critical function of mitochondria is to interact intimately with other organelles of the cell, especially peroxisomes, to create cellular homeostasis. [3]

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As a waste product, mitochondria produce free radicals, which must be neutralized. If the mitochondria are damaged beyond repair, the cell would not be able to function as it was designed. For example, a liver cell would not be able to function as a healthy liver cell; a brain cell would not be able to function as a healthy brain cell; a gum tissue cell would not be able to function as a healthy gum tissue cell. In some situations, the cell might begin to replicate out-of-control and become cancerous.

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Gum Disease & Mitochondria

When everything is working correctly, the mitochondria are healthy and functioning at the top of their game. Problems develop when our mitochondria are compromised. Gum disease is one result of dysfunction in the mitochondria within gum tissue cells. [4]

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So, it appears that healthy mitochondria are critical for our oral health, for our cells’ health, and for our existence. Healthy mitochondria are supported by nutrient-dense foods, efficient exercise, restorative sleep, and reduction of stress. If mitochondria are not firing on all cylinders, disease will occur. In the past, I wrote about exercise and how it benefits healthy mitochondria. [5]

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Also, the gut microbiome is important for the health of mitochondria. The beneficial bacteria in the gut will produce butyrate, other short chain fatty acids, and lactate from fiber as well as urolithin-A from tannins in food. These metabolites from beneficial bacteria feed healthy mitochondria, support the cells that line the colon, and actually increase diversity in healthy gut bacteria. Since ancient bacteria were the precursors of our modern-day mitochondria, the needs of the mitochondria in our cells are similar to the needs of healthy gut bacteria. There is actually “cross communication” between our gut microbiome and our mitochondria.

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Another important nutrient in all of this is vitamin K2. Vitamin K2 is produced by healthy gut bacteria. This vitamin is also available in some fermented foods, organ meats, egg yolks, and grass-fed dairy. Vitamin K2 appears to assist mitochondria by increasing their capacity to create energy.

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So, what will cause mitochondria to malfunction? Mitochondria can become damaged and dysfunctional when necessary nutrients are not available from the gut, when the energy created by mitochondria is less than the free radicals they produce, and when mitochondria are unable to repair themselves or increase their numbers in their host cell. Also, specific environmental elements and medications can be toxic to mitochondria. These include xenoestrogens (estrogen imitators) in the environment, acetaminophen (Tylenol), statins (anti-cholesterol drugs), glyphosate (Roundup), and heavy metals like lead, mercury, and aluminum.

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Kiran Krishnan, the microbiologist and Chief Science Officer of Microbiome Labs, created a webinar about the interplay between healthy gut bacteria, strong mitochondria, and vitamin K2. [6]

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My Protocol

Based on the research I have uncovered and the information Kiran Krishnan provided and documented in his webinar, I want to assist my patients who have gum disease. Supporting healthy mitochondria must be considered with gum treatment. Current research suggests that supporting the mitochondria’s ability to maintain homeostasis in the cell might be lifesaving. [7] To that end, clinical treatment of active gum disease along with supplements, which support healthy mitochondria, could be an ideal protocol to treat periodontal disease.

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I first treat active gum disease by removing local irritants from under the gum tissues and by teaching effective oral hygiene. When advanced gum disease has created jawbone damage, I use the LANAP (Laser Assisted New Attachment Procedure) Protocol [8] to assist the body in regenerating new bone around damaged teeth. [9],[10]

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In addition, I encourage my patients to eat nutrient-dense foods and remove the foods that damage the gut. I’ve written about nutrient-dense, anti-inflammatory foods and a primal lifestyle to support overall health. [11] I even discussed this as it applied to my personal life’s challenges. [12]

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Furthermore, I recommend three supplements to support healthy mitochondria – a probiotic called MegasporeBiotic [13], a vitamin K2 supplement called MegaQuinone K2-7 [14], and a mixture of prebiotic fibers to feed the healthy gut microbiome called PaleoFiber [15].

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Probiotic, Vitamin K2, & Prebiotic

MegasporeBiotic is a unique probiotic that can survive the stomach acidity and set up residence in the intestines. It will increase the population of healthy bacteria in the gut and increase the bacteria’s production of butyrate, urolithin-A, and lactate. This probiotic is supplied by Microbiome Labs.

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MegaQuinone K2-7 is a blend of vitamin K2 and several nutrients required by vitamin K2 to enhance the efficiency of the mitochondria. This K2 supplement also is supplied by Microbiome Labs. (Patients taking certain blood thinners may not be able to take this product.)

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PaleoFiber is a combination of fibers derived from fruits, vegetables, roots, seeds, and tree extracts to feed the beneficial bacteria in the gut. This product is supplied by Designs for Health.

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Dosing:

  • Take two capsules of MegasporeBiotic once a day about 10-20 minutes after a meal so that it can begin providing benefits in the upper intestinal tract. However, it might be necessary to take a smaller dose of the probiotic for a few days and work up to the ideal dose as your body gets used to the probiotic.
  • Take one capsule of MegaQuinone K2-7 with your first meal of the day that contains fat and then another capsule with your last meal of the day that contains fat.
  • Take 2-3 teaspoons of PaleoFiber per day with water or any liquid. You could take it at any time, and you could take more if necessary.

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My recommendation is to take these for at least 60 days. Then, determine the health of the gum tissues. It may or may not be necessary to continue to take these supplements in the future. Some people may want to take them on a regular basis for overall health and quality of life.

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My Patient Was Taking
Too Much Vitamin D

Alvin H. Danenberg, DDS     Nutritional Periodontist
October 10, 2016  

vitamin-dA couple of months ago, Craig made an appointment with me. He was concerned about his advanced gum disease. As I was reviewing his medical history, he explained that he was taking 10,000 IU of Vitamin D3 a day. When I asked him why, he said that he was told that there were no problems with high doses of Vitamin D and that it was supposed to be good for gum disease.

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He was taking too much Vitamin D!

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Facts

The facts are:

  • Vitamin D is critical for overall health including the health of the gum tissues.
  • Vitamin D needs other vitamins and nutrients to function properly.
  • Long-term use of high doses of Vitamin D as a supplement can be life threatening.

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When it comes to Vitamin D as a supplement, there is a “U-shaped” curve for the dose that is healthy. Too little Vitamin D causes various diseases; too much may cause various diseases; and somewhere in the middle is critical for health. I wrote about the benefits of Vitamin D in the past (HERE). However, taking excessive Vitamin D supplementation can create blood levels that have been linked to decreased bone density and increased heart attacks, strokes, and particularly kidney stones (HERE. HERE).

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The only way a person can determine if she or he has a healthy blood level of Vitamin D is to have a special blood test. Craig never had this test to determine his level of Vitamin D. A blood test called “25 Hydroxy Vitamin D” is a test that shows how much of this active form of Vitamin D is in circulation. When he had his blood tested for 25 Hydroxy Vitamin D, it was 110 ng/mL. The normal functional range is between 35-60 ng/mL. I told him to stop taking his daily 10,000 IU dose of Vitamin D3.

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Sources Of Vitamin D

The best source of Vitamin D is the sun – not to the point that you get sunburn but just to the point that you develop adequate Vitamin D in the skin surface. How much sun will do this? That depends on skin color, physical location from the equator, time of year, time of day, how much clothing is worn, age, weight, and other factors. For example, one person might need 15 minutes of midday sun to get an adequate amount of Vitamin D creation while another person in the same location might require 60 minutes to get the same level of Vitamin D.

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The second best source is food. Since I generally am not a fan of individual supplements, I want to get my necessary nutrients from nutrient-dense, anti-inflammatory foods. Some foods that have significant levels of Vitamin D are cod liver oil, wild caught salmon, mackerel, herring, sardines, and pastured eggs. In addition, these foods and various nutrient-dense foods provide the essential nutrients to make Vitamin D do what it is supposed to do in the body.

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The third best source is Vitamin D supplements. There are two options – Vitamin D3 and Vitamin D2. Vitamin D3 appears to be better absorbed and to create more Vitamin D in circulation than Vitamin D2. However, it’s important to take Vitamin D supplements along with fats since Vitamin D is fat-soluble. Also, it is essential to include adequate sources of Vitamin A and Vitamin K2, which have been shown to be essential for Vitamin D to work correctly and to prevent Vitamin D toxicity (HERE). Other nutrients like potassium and magnesium are also important for vitamin D to do what it is supposed to do.

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Final Thoughts

Vitamin D is critical for health. Vitamin D requires necessary nutrients to function properly. It is so easy to take supplements without knowing how much Vitamin D is in your system. The only way to determine your blood level is to have proper blood tests done. Excessive blood levels may not be obvious until you have a blood test. Overdosing on Vitamin D supplements could be life threatening.

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